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Mistelihoidon näyttö kliinisissä tutkimuksissa

Hoitoväsymys (Fatigue-oireyhtymä)

Kröz, M., Quittel, F., Reif, M. et al. Four-year follow-up on fatigue and sleep quality of a three-armed partly randomized controlled study in breast cancer survivors with cancer-related fatigue. Sci Rep 13, 2705 (2023).


Pelzer F, Loef M, Martin DD, Baumgartner S. Cancer related fatigue in patients treated with mistletoe extracts: a systematic review and meta analysis . Supportive Care in Cancer 2022.

Open access DOI:

Zerm R, Müller-Glinz A, Pranga D, Reif M, Bartsch C, Heckmann C, Gutenbrunner C, Kröz M. Influence of multimodal treatment on rest/activity and autonomic regulation in breast cancer patients with cancer related fatigue - results of a tri-center trial with a comprehensive cohort design, Complement Med Res. (2022).

Schad F, Thronicke A, von Trott P, Oei SL: Analysis of changes in cancer-related fatigue of breast cancer patients receiving an integrative medicine program. Integrative Cancer Therapies 2020, 19. 12 pp. DOI: 10.1177/1534735420963780.


Oei SL, Thronicke A, Kröz, M, von Trott P, Schad F, Matthes, H. Impact of Oncological Therapy and Viscum album L Treatment on Cancer-Related Fatigue and Internal Coherence in Nonmetastasized Breast Cancer Patients. Integr Cancer Ther. 2020;19:1534735420917211. doi: 10.1177/1534735420917211

Ben-Arye E, Dahan O, Shalom-Sharabi I, Samuels N. Inverse relationship between reduced fatigue and severity of anemia in oncology patients treated with integrative medicine: understanding the paradox. Supportive Care in Cancer 2018; 10 pp. DOI: 10.1007/s00520-018-4271-5

Tröger W, Zdrale Z, Tisma N and Matijasevic M. Additional Therapy with a Mistletoe Product during Adjuvant Chemotherapy of Breast Cancer Patients Improves Quality of Life: An Open Randomized Clinical Pilot Trial. Evidence-Based Complementary and Alternative Medicine, 2014;2014:01. Sep. DOI: 10.1155/2014/430518

Tröger W, Galun D, Reif M, Schumann A, Stankovic N and Milicevic M. Quality of life of patients with advanced pancreatic cancer during treatment with mistletoe: a randomized controlled trial. Dtsch Arztebl Int, 2014;111:493-502, 433 p following 502. DOI: 10.3238/arztebl.2014.0493


Zaenker KS, Matthes H, Bock PR, Hanisch J (2012) A Specific Mistletoe Preparation (Iscador-Qu®) in Colorectal Cancer (CRC) Patients: More than Just Supportive Care? J Cancer Sci Ther 4: 264-270. doi: 10.4172/1948-5956.1000153


Matthes H, Friedel W E, Bock P R and Zanker K S. Molecular mistletoe therapy: friend or foe in established anti-tumor protocols? A multicenter, controlled, retrospective pharmaco-epidemiological study in pancreas cancer. Curr Mol Med, 2010;10:430-439. DOI: 10.2174/156652410791317057


Wode K, Schneider T, Lundberg I and Kienle G S. Mistletoe treatment in cancer-related fatigue: a case report. Cases J, 2009;2:77. DOI: 10.1186/1757-1626-2-77


Tröger W, Jezdic S, Zdrale Z, Tisma N, Hamre H J and Matijasevic M. Quality of life and neutropenia in patients with early stage breast cancer: a randomized pilot study comparing additional treatment with mistletoe extract to chemotherapy alone. Breast Cancer, 2009;16:35-45


Friedel W E, Matthes H, Bock P R and Zanker K S. Systematic evaluation of the clinical effects of supportive mistletoe treatment within chemo- and/or radiotherapy protocols and long-term mistletoe application in nonmetastatic colorectal carcinoma: multicenter, controlled, observational cohort study. J Soc Integr Oncol 2009;7:137-145


Bock P R, Friedel W E, Hanisch J, Karasmann M and Schneider B. [Efficacy and safety of long-term complementary treatment with standardized European mistletoe extract (Viscum album L.) in addition to the conventional adjuvant oncologic therapy in patients with primary non-metastasized mammary carcinoma. Results of a multi-center, comparative, epidemiological cohort study in Germany and Switzerland]. Arzneimittelforschung, 2004;54:456-466. DOI: 10.1055/s-0031-1296999

Kröz M, Büssing A, Reif M, Pranga D, Schad F, Zerm R, Matthes H and Girke M. Besteht eine Indikation für die Misteltherapie in der Behandlung von Cancer-related Fatigue und Insomnie bei Krebspatienten? –  Ein Review In: Scheer R, Alban S, Becker H, Beer A-M, Blaschek W, Kreis W, et al., editors. Die Mistel in der Tumortherapie 4 Aktueller Stand der Forschung und klinische Anwendung: KVC Verlag, Essen, 287-298; 2016.

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