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Mistelihoidon aineosat  ja vaikutus

Vaikutukset syöpäsolujen fysiologiaan
In vivo -tutkimukset soluviljelmissä ja eläinmalleilla

Menke K, Schwermer M, Eisenbraun J, Schramm A, Zuzak TJ: Anticancer effects of Viscum album Fraxini extract on medulloblastoma cells in vitro. Complementary Medicine Research 2020. 8 pp. DOI: 10.1159/000507318.


Tsekouras V, Mavrikou S, Vlachakis D, Makridakis M, Stroggilos R, Zoidakis J, Termentzi A, Moschopoulou G, Kintzios S: Proteome analysis of leaf, stem and callus in Viscum album and identification of lectins and viscotoxins with bioactive properties. Plant Cell, Tissue and Organ Culture 2020, 141 (1), 167-178. DOI: 10.1007/s11240-020-01777-7.


Holandino C, Nonato de Oliveira Melo M, Passos Oliveira A, da Costa Batista JV, Alves Marques Capella M, Garrett R, Grazi M, Ramm H, Dalla Torre C, Schaller G, Urech K, Weissenstein U, Baumgartner S: Phytochemical analysis and in vitro anti-proliferative activity of Viscum album ethanolic extracts. BMC Complementary Medicine and Therapies 2020, 20, 215. 11 pp. DOI: 10.1186/s12906-020-02987-4.

Menke K, Schwermer M, Schramm A, Zuzak T. Preclinical evaluation of antitumoral and cytotoxic properties of Viscum album Fraxini extract on pediatric tumor cells. Planta Medica 2019, 85 (14-15), 1150-1159. DOI: 10.1055/a-1013-0382.

Yang P, Jiang Y, Pan Y, Ding X, Rhea P, Ding J, Hawke DH, Felsher D, Narla G, Lu Z, Lee RT. Mistletoe extract Fraxini inhibits the proliferation of liver cancer by downregulating c-Myc expression. Scientific Reports 2019;9: 12 pp. DOI: 10.1038/s41598-019-41444-2.

Felenda JE, Turek C, Stintzing FC. Antiproliferative potential from aqueous Viscum album L. preparations and their main constituents in comparison with ricin and purothionin on human cancer cells. Journal of Ethnopharmacology 2019;236:100-107. DOI: 10.1016/j.jep.2019.02.047.

Felenda JE, Gruber K, Pacifico S, Turek C, Beckmann C, Stintzing FC. In-vitro-Untersuchungen zur Weidenmistel an verschiedenen humanen Tumorzelllinien. Zeitschrift für Phytotherapie 2019;40(3):112-119. DOI: 10.1055/a-0799-7042.

Felenda JE, Gruber K and Stintzing F. In-vitro-Untersuchungen zur Hemmung der Angiogenese und der Tumorzellmigration durch einen wässrigen Extrakt aus Viscum album ssp. album, Mali. June 2019. Deutsche Zeitschrift für Onkologie 2019;51(02):81-88. DOI: 10.1055/a-0827-9646  

Kleinsimon, S, Longmuss, E, Rolff, J, et al. GADD45A and CDKN1A are involved in apoptosis and cell cycle modulatory effects of viscumTT with further inactivation of the STAT3 pathway. Sci Rep. 2018;8(1):5750. doi:10.1038/s41598-018-24075-x 
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Schötterl S, Huber SM, Lentzen H, Mittelbronn M, Naumann U.Adjuvant therapy using mistletoe containing drugs boosts the T-cell-mediated killing of glioma cells and prolongs the survival of glioma bearing mice. Evidence-Based Complementary and Alternative Medicine 2018. Article ID 3928572. 12 pp. DOI: 10.1155/2018/3928572.

Stammer RM, Kleinsimon S, Rolff J, Jäger S, Eggert A, Seifert G, Delebinski CI (2017) Synergistic antitumour properties of viscumTT in alveolar rhabdomyosarcoma. Journal of Immunology Research 2017. 13 pp. Article ID 4874280. DOI: 10.1155/2017/4874280

Twardziok, M, Meierhofer, D, Börno, S, et al. Transcriptomic and proteomic insight into the effects of a defined European mistletoe extract in ewing sarcoma cells reveals cellular stress responses. BMC Complement Altern Med. 2017;17(1):237. doi:10.1186/s12906-017-1715-2 
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Mulsow K, Enzlein T, Delebinski C, Jaeger S, Seifert G and Melzig MF. Impact of Mistletoe Triterpene Acids on the Uptake of Mistletoe Lectin by Cultured Tumor Cells. PLOS One 2016;11: e0153825 

Twardziok, M, Kleinsimon, S, Rolff, J, et al. Multiple active compounds from Viscum album L. synergistically converge to promote apoptosis in ewing sarcoma. PLoS One. 2016;11(9):e0159749. doi:10.1371/journal.pone.0159749 
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Elluru, SR, Duong Van Huyen, J-P, Delignat, S, et al. Antiangiogenic properties of viscum album extracts are associated with endothelial cytotoxicity. Anticancer Res. 2009;29(8):2945-2950. Google Scholar | Medline


Seifert, G, Jesse, P, Laengler, A, et al. Molecular mechanisms of mistletoe plant extract-induced apoptosis in acute lymphoblastic leukemia in vivo and in vitro. Cancer Lett. 2008;264(2):218-228. doi:10.1016/j.canlet.2008.01.036 
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Urech K, Schaller G and Jaggy C. Viscotoxins, mistletoe lectins and their isoforms in mistletoe (Viscum album L.) extracts Iscador. Arzneimittelforschung, 2006;56:428-434. DOI: 10.1055/s-0031-1296808


Kovacs E, Link S and Toffol-Schmidt U. Cytostatic and cytocidal effects of mistletoe (Viscum album L.) quercus extract Iscador. Arzneimittelforschung, 2006;56:467-473. DOI: 10.1055/s-0031-1296814

Maldacker J. Preclinical investigations with mistletoe (Viscum album L.) extract Iscador. Arzneimittelforschung, 2006;56:497-507. DOI: 10.1055/s-0031-1296817

Urech K, Büssing A, Thalmann G, Schäfermeyer H and Heusser P. Antiproliferative effects of mistletoe (Viscum album L) extract in urinary bladder carcinoma cell lines. Anti-Cancer Research 2006;26:3049-3056.

van Huyen JPD, Delignat S, Bayry J, Kazatchkine MD, Bruneva IP, Nicoletti A and Kaveri SV. Interleukin-12 is associated with the in vivo anti-tumor effect of mistletoe extracts in B16 mouse melanoma. Cancer Lett 2006;243:32-37.

Harmsma, M, Ummelen, M, Dignef, W, Tusenius, KJ, Ramaekers, FCS. Effects of mistletoe (Viscum album L.) extracts iscador on cell cycle and survival of tumor cells. Arzneimittelforschung. 2006;56(6A):474-482. doi:10.1055/s-0031-1296815 
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Urech K, Scher JM, Hostanska K and Becker H. Apoptosis inducing activity of

viscin, a lipophilic extract from Viscum album L. J Pharm Pharmacol 2005;57:101-


Pae HO, Oh GS, Seo WG, Shin MK, Hong SG, Lee HS and Chung HT. Mistletoe lectin synergizes with paclitaxel in human SK-hep1 hepatocarcinoma cells. Immunopharmacol Immunotoxicol 2001;23: 531-540.

Büssing A, Vervecken W, Wagner M, Wagner B, Pfuller U and Schietzel M. Expression of mitochondrial Apo2.7 molecules and caspase-3 activation in human lymphocytes treated with the ribosome-inhibiting mistletoe lectins and the cell membrane permeabilizing viscotoxins. Cytometry, 1999;37:133-139

Büssing A and Schietzel M. Apoptosis-inducing properties of Viscum album L. extracts from different host trees, correlate with their content of toxic mistletoe lectins. Anticancer Res, 1999;19:23-28

Büssing A, Schaller G and Pfuller U. Generation of reactive oxygen intermediates (ROI) by the thionins from Viscum album L. Anticancer Res, 1998;18:4291-4296

Büssing A, Suzart K, Bergmann J, Pfuller U, Schietzel M and Schweizer K. Induction of apoptosis in human lymphocytes treated with Viscum album L. is mediated by the mistletoe lectins. Cancer Lett, 1996;99:59-72. DOI: 10.1016/0304-3835(95)04038-2

Janssen O, Scheffler A and Kabelitz D. In vitro effects of mistletoe extracts and mistletoe lectins. Cytotoxicity towards tumor cells due to the induction of programmed cell death (apoptosis). Arzneimittelforschung, 1993;43:1221-1227

Mueller EA and Anderer FA. A Viscum album oligosaccharide activating human natural cytotoxicity is an interferon gamma inducer. Cancer Immunol Immunother 1990;32:221-227

Stettin A, Schultze JL, Stechemesser E and Berg PA. Anti-mistletoe lectin antibodies are produced in patients during therapy with an aqueous mistletoe extract derived from Viscum album L. and neutralize lectin-induced cytotoxicity in vitro. Klin Wochenschr 1990;68:896-900

Klett CY and Anderer FA. Activation of natural killer cell cytotoxicity of human blood monocytes by a low molecular weight component from viscum album extract. Arzneimittelforschung 1989;39:1580-1585.

Kuttan G, Vasudevan DM and R Kuttan R. Isolation and identification of a tumour reducing component from mistletoe extract (Iscador). Cancer Lett 1988;41:307-314

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